J. Blas, J. Carretero, E. Dominguez
Jun 27, 1994
Citations
0
Influential Citations
22
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A highly stereoselective procedure for the preparation of a variety of syn 2-amino alcohol derivatives from enantiopure E-γ-hydroxy-α,β-unsaturated phenyl sulfones is described. The method is based on an intramolecular carbamate cyclization, followed by functionalization at α-position by reaction of the sulfonyl carbanion with electrophiles, and subsequent elimination of the sulfonyl group.