A. V. Tverdokhlebov, Elizaveta V. Resnyanska, A. Tolmachev
Dec 1, 2003
Citations
0
Influential Citations
16
Citations
Journal
Synthesis
Abstract
5-Aroyl-2-(dimethylamino)methylidene-2,3-dihydro-3-oxopyrrolo[2,1-b]thiazole-7-carboxylic acid esters, -7-carbonitriles and corresponding 7-hetaryl substituted derivatives were prepared. Thus, the substituted acetonitriles (XCH 2 CN, where X = CO 2 R, CN, hetaryl) were treated with mercaptoacetic acid yielding 2-(X-methylidene)thiazolidin-4-ones, which were N-alkylated with phenacyl bromides. Further formylation of the obtained compounds with excess of DMF.POCl 3 complex led to the above mentioned pyrrolo[2,1-b]thiazoles.