Donna M. Garey, Mai-ly Ramirez Ml, Sam Gonzales
Sep 1, 1995
Citations
0
Influential Citations
31
Citations
Journal
The Journal of organic chemistry
Abstract
We examined a method for the preparation of 4-hydroxypyran-2-ones in two steps from aryl ketones and ethyl malonyl chloride (or ethyl 2-methylmalonyl chloride). These 4-hydroxypyran-2-ones are useful precursors as they may be transformed in two steps to the 2-methoxypyran-4-ones, which is found in phenoxan—a naturally occurring compound discovered to have anti-HIV activity.