P. RAJA GOPAL, E. R. R. Chandrashekar, M. Saravanan
Oct 12, 2012
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Journal
Journal of Chemical Sciences
Abstract
AbstractA practical synthesis of (2-butyl-5-nitrobenzofuran-3-yl)(4-hydroxyphenyl)methanone, a key intermediate in the preparation of anti arrhythmic drug, is described. The commercially available 4-nitrophenol (3) is converted in five steps to 2-butyl-5-nitrobenzofuran (9) which upon Friedel–Crafts acylation with 4-methoxybenzoyl chloride followed by deprotection of methyl group gives (2). Graphical AbstractAn alternative approach for the synthesis of (2-butyl-5-nitrobenzofuran-3-yl)(4-hydroxyphenyl)methanone, a key starting material for dronedarone hydrochloride using commercially available p-nitrophenol as a starting material is described.