Fuchao Yu, Bei Zhou, Hui Xu
Feb 4, 2015
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0
Influential Citations
33
Citations
Journal
Tetrahedron Letters
Abstract
We report the first oxidative condensation between N,N-dimethylenaminones with amines to form 1,4-dihydropyridines in moderate to good yields, promoted by oxone and trifluoroacetic acid in PEG-400. This reaction features an unusual oxidation of in situ formed dimethylamine to efficiently provide the 4-methylene of 1,4-dihydropyridines, and a highly environment-friendly reaction condition.