H. Mehrabi, Farzaneh Alizadeh-bami, F. Askarzadeh
Nov 25, 2022
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Journal
Arkivoc
Abstract
A simple and efficient method for the synthesis of 2-(2-(aryl)naphtho[2,1-b ]furan-1-yl)acetic acid derivatives via an one-pot three-component reaction of Meldrum's acid, arylglyoxals, and β -naphthol in the presence of triethylamine (Et 3 N) is reported. The protocol avoids the use of expensive catalysts, chromatographic separation and provides a wide range of novel naphtho[2,1-b ]furans in excellent yields. Spectral data and elemental analysis have characterized the newly synthesized compounds.