P. Salehi, M. Dabiri, M. Zolfigol
Oct 10, 2005
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Journal
Tetrahedron Letters
Abstract
Quinazolin-4(3H)-one derivatives were synthesized successfully via a one-pot, three component reaction of isatoic anhydride and an orthoester with ammonium acetate or a primary amine catalyzed by silica sulfuric acid under solvent-free conditions. This is the first report on the synthesis of 2-substituted quinazolin-4(3H)-ones by this procedure.