A. Khodair, P. Bertrand
May 7, 1998
Citations
0
Influential Citations
65
Citations
Journal
Tetrahedron
Abstract
Abstract 5-((Z)-Arylidene)-2-((2-(E)-benzylidene)hydrazone)-4-imidazolidinones 7a-d and 5-((Z)-arylidene)-2-((2-(E)-polyhydroxyalkylidene)hydrazono)-4-imidazolidinones 11a-d to 15a-d were prepared from the reaction of 5-((Z)-arylidene)-2-methylmercaptohydantoins 3a-d with 2-(E)-benzylidene hydrazone 6 or 2-(E)-monosaccharides hydrazones 9a-e, which in turn were prepared by condensation of benzaldehyde or appropriate monosaccharides 8a-e with hydrazine hydrate. AM1 semi-empirical calculations reveal that the azine system is favoured with a trans geometry and planar conformation for CN-NC. All the new compounds were tested for their potential antiviral and antitumor activities.