T. Yamane, H. Mitsudera, Takatsugu Shundoh
Oct 7, 2004
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0
Influential Citations
3
Citations
Journal
Synthesis
Abstract
A simple and efficient method for the synthesis of 2-aryl 4-bromomethyl-5-methyl-1,3-oxazoles 2 and 2-aryl-4-chlorometh yl-5-methyl-1.3-oxazoles 3 is described. The reaction of 2-aryl-4,5 dimethyl-1,3-oxazoles 1 with N-bromosuccinimide and N-chloro succinimide in acetonitrile under mild conditions provides 4-ha lomethyl isomers with exceptionally high regioselectivity ir moderate to good yields.