Weibing. Liu, L. Tan, P. Zhou
Mar 22, 2013
Citations
0
Influential Citations
9
Citations
Journal
Synlett
Abstract
A simple and concise tandem cyclization of alkynoates with amines in the presence of tert-butyl perbenzoate (TBPB) leads to 1,2,4-trisubstituted 1H-pyrroles. A variety of aromatic amines and aliphatic amines can be used in this approach, and a wide range of functionalized 1,2,4-trisubstituted 1H-pyrroles are obtained in good to excellent yields. This protocol not only corresponds to the construction of a pyrrole fragment, but also provides a new way to form C–C and C–N bonds.