N. Desai, H. Vaghani, P. N. Shihora
Sep 1, 2013
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Influential Citations
15
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Quality indicators
Journal
Journal of Fluorine Chemistry
Abstract
Abstract We have synthesized some novel fluorine containing 5-arylidene derivatives bearing different pharmacophores and heterocyclic systems like quinazolinone along with 4-thiazolidinone, which may act as potential antimicrobial agents. They have been synthesized by the Knoevenagel condensation of N -(2-(4-fluorophenyl)-4-oxothiazolidin-3-yl)-4-(4-oxo-2-p-tolylquinazolin-3(4H)-yl)benzamide with aromatic aldehydes to form N -(5-(aryl)-2-(4-fluorophenyl)-4-oxothiazolidin-3-yl)-4-(4-oxo-2-p-tolylquinazolin-3(4 H )-yl)benzamides ( 6a–t) . The products were characterized by IR, 1 H, 13 C and 19 F NMR and mass spectral techniques. The synthesized compounds were evaluated for their in vitro antimicrobial activity against Gram-positive bacteria ( Staphylococcus aureus and Streptococcus pyogenes ), Gram-negative bacteria ( Escherichia coli and Pseudomonas aeruginosa ) and fungi ( Candida albicans , Aspergillus niger , and Aspergillus clavatus ) using serial broth dilution method. Compounds 6b , 6d , 6i , 6j , 6k, 6n and 6s were the most noteworthy derivatives identified in the present study because of their remarkable in vitro antimicrobial potency.