G. O'Doherty, M. H. Haukaas, Miaosheng Li
Nov 1, 2008
Citations
0
Influential Citations
9
Citations
Journal
Heterocycles
Abstract
Several methods were investigated for the de novo asymmetric synthesis of 2-amino-N-(benzyloxycarbonyl)-1-(2'-furyl)ethanol and 2-amino-N-(tert-butoxycarbonyl)-1-(2'-furyl)ethanol. A five step procedure was developed for the practical preparation of optically pure 2-amino-N-(benzyloxycarbonyl)-1-(2'-furyl)ethanol and a shorter 2-step procedure was developed for 2-amino-N-(tert-butoxycarbonyl)-1-(2'-furyl)ethanol. Both routes used a Noyori reduction to install the asymmetry.