A. Arcadi, S. Cacchi*, S. D. Giuseppe
Mar 1, 2002
Citations
0
Influential Citations
35
Citations
Journal
Synlett
Abstract
2-Ethynyl-3-pyridinols and 3-ethynyl-2-pyridinols, readily available from halopyridinols, have been treated with aryl/ heteroaryl halides or vinyl triflates to give 2-substituted furo[3,2-b]pyridines and 2-substituted furo[2,3-b]pyridines through a coupling/cyclization process. Two catalyst systems have been used: PdCl 2 (PPh 3 ) 2 -CuI and Pd 2 (dba) 3 -P(t-Bu) 3 . Halopyridinols have been employed for an alternative approach to 2-substituted furo[2,3-b]pyridines and 2-substituted furo[2,3-c]pyridines via 2-(trimethylsilyl)furopyridines, 2-iodofuropyridines, palladiumcatalyzed reactions.