S. Raw, R. Taylor
Dec 23, 2000
Citations
0
Influential Citations
15
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Both 2 E - and 2 Z -3-iodoacrolein O -methyl oximes are prepared in two steps from ethyl propiolate. Lithium–iodine exchange is effected and the resulting organolithium reagents added to several electrophiles, including styryl isocyanate which gives a conjugated O -methyl oxime enamide of the type found in the side chains of the oximidine, lobatamide and CJ-12950 natural products. The Pd(0) catalysed cross-coupling of these iodoalkenes is also explored.