K. Hamano, M. Kinoshita-Okami, K. Minagawa
Nov 25, 1993
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Influential Citations
18
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Journal
The Journal of antibiotics
Abstract
A new inhibitor of mammalian adenosine triphosphatases, designated aquastatin A, has been isolated from a fungus identified as Fusarium aquaeductuum. The structure of this compound has been determined by MS and NMR analyses. It inhibits Na+/K(+)-ATPase with an IC50 value of 7.1 microM, and H+/K(+)-ATPase with an apparent IC50 value of 6.2 microM.