D. Sevenard, O. Kazakova, Ralf‐Matthias Schoth
May 16, 2008
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Synthesis
Abstract
An efficient and reliable method to synthesize 2,6- bis(trifluoroacetyl)phenols bearing various substituents in the 4-po- sition was developed. These valuable fluorinated building blocks were obtained from the corresponding cyclohexanones in a facile and convenient procedure, demonstrated to be superior to the tradi- tional approaches. The application of this methodology to cyclohex- ane-1,4-dione opened access to 2,5-bis(polyfluoroacyl)-1,4- hydroquinones. Structural peculiarities of the obtained phenols as well as their 1,3-dicarbonyl or 1,3,5-tricarbonyl precursors are dis- cussed on the basis of multinuclear NMR spectroscopy.