D. Aviado
Mar 1, 1960
Citations
1
Influential Citations
37
Citations
Journal
Circulation Research
Abstract
I N RECENT years, 8 drugs have been used clinically to block autonomic ganglia. Such drugs are as follows •. (a) tetraethylammoiiium chloride (Etamon) ; (b) hexamethonium chloride or bromide (Bistrium, Esomid, Hexameton, Methium) ; (c) pentamethonium chloride or bromide; (d) azamethonium chloride (Pendiomide) ; (e) pentoliniuni tartrate (Ansolysen) ; (f) trimethaphan camphorsulfonate (Arf'ouad) ; (g) chlorisondamine chloride (Ecolid) ; and (h) mecamylamine hydrochloride (Inversine). The intravenous administration of a sufficient dose of each of these drugs causes significant reduction in systemic arterial blood pressures of the normotensive or hypertensive subject. Numerous hemodynamic measurements haA'e appeared for all these drugs except (g) and (h), which have been introduced recently. This article will review the clinical reports with the primary intention of characterizing the hemodynamic situation induced by ganglion blocking drugs. The effects of drugs will be discussed in terms of changes in cardiac output, systemic vascular resistance and vascular resistance of the coronary, cerebral, renal, splanchnic, limb and pulmonary vascular beds.