Jialin Ming, Tamio Hayashi
Dec 6, 2016
Citations
0
Influential Citations
21
Citations
Journal
Organic letters
Abstract
Reaction of potassium aryloxymethyltrifluoroborates 1 with α,β-unsaturated carbonyl compounds 2 in the presence of a chiral diene-rhodium catalyst in H2O at 100 °C introduced 2-methoxyaryl groups at the β-position of 2 with high enantioselectivity in high yields. The reaction is assumed to proceed through 1,4-Rh shift from aryloxymethyl-Rh intermediate to 2-methoxyaryl-Rh. The high availability of phenol derivatives makes this asymmetric conjugate arylation synthetically useful.