M. Duncton, Evgueni L. Piatnitski, R. Katoch-Rouse
Mar 15, 2006
Citations
0
Influential Citations
31
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
A novel class of 1-(isoquinolin-5-yl)-4-arylamino-phthalazines is described as inhibitors of vascular endothelial growth factor receptor II (VEGFR-2). Many compounds display VEGFR-2 inhibitory activity with an IC(50) as low as 0.017 microM in an HTRF enzymatic assay. The compounds also inhibit VEGFR-1, a related tyrosine kinase.