M. Haka, M. Kilbourn, G. L. Watkins
Jul 1, 1989
Citations
1
Influential Citations
168
Citations
Quality indicators
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
Aromatic nucleophilic substitution of various trimethylammonium trifluoromethanesulfonates with [18F]fluoride has been evaluated. Fluorinations were studied over a temperature range of 45–165°C, with decay corrected yields ranging from 20–80%. [18F]GBR 13119, 1-[2-{(4-[18F]fluorophenyl)(phenyl)methoxy}ethyl]-4-(3-phenylpropyl)piperazine, a potential radio-tracer for the dopamine uptake system, has been prepared in no-carrier-added form from 4-N,N,N,-trimethylaniliniumphenylmethanone trifluoromethanesulfonate. Purification by solid-phase techniques yielded the product in 20% decay corrected radiochemical yield and >98% radiochemical and chemical purity without HPLC.