B. Sokoloff, W. H. Eddy, R. Powella
May 1, 1954
Citations
0
Influential Citations
5
Citations
Quality indicators
Journal
Cancer research
Abstract
Summary d-Glucoascorbic acid added to a Sherman-LaMer scorbutogenic diet at a level of 0.75 or 1.0 per cent produced no apparent toxic effect on mice, but on this diet the ascorbic acid concentrations of the blood plasma, spleen, and adrenals were considerably lowered in 12–15 days. Continuous feeding of a Sherman-LaMer ration containing 0.75 per cent of d-glucoascorbic acid for 2 weeks had no effect on the course of transplanted acute lymphocytic leukemia in the hybrid mice Ak-Bc. Continuous feeding of a Sherman-LaMer ration containing 0.75 per cent of d-glucoascorbic acid to Ak-1m mice of 2 and 5 months of age did not affect the incidence of lymphocytic leukemia but prolonged the life span of leukemic mice by 26.8 and 18.4 per cent, respectively. Administration of cortisone acetate, 0.5 mg. daily, for 5 consecutive days, once every month, to the 5-month-old Ak-1m mice kept on a Sherman-LaMer diet containing 0.75 per cent of d-glucoascorbic acid, decreased the incidence of leukemia from 75 to 50 per cent and prolonged the life span of mice by 67.5 per cent.