B. Sokoloff, W. H. Eddy, R. Powella
Sep 1, 1953
Citations
0
Influential Citations
8
Citations
Quality indicators
Journal
Cancer research
Abstract
Summary When d-glucoascorbic acid was added to a Sherman-LaMer scorbutogenic diet at a level of 1 or 2 per cent, no apparent toxic effects such as diarrhea, alopecia, or hemorrhagia in rats and mice was produced, but on this diet the ascorbic acid concentrations of the blood plasma and certain tissues were lowered to nearly zero in 20 days. Intraperitoneal injection of 250 mg/kg/day of d-glucoascorbic acid for 7 days did not retard the growth of mouse Sarcoma 180 and only slightly inhibited the Crocker rat carcinoma and mouse adenocarcinoma E 0771. Continuous feeding of a Sherman-LaMer ration containing 1 or 2 per cent of d-glucoascorbic acid for 4 weeks considerably retarded the Crocker carcinoma and adenocarcinoma E 0771. d-Glucoascorbic acid did not affect the growth of liposarcoma in guinea pigs receiving an adequate supply of vitamin C, although the tumor growth was retarded considerably in scorbutic guinea pigs. In the absence of dietary ascorbic acid, the urinary excretion of the citrovorum factor in rats was decreased by a diet containing 1 or 2 per cent of the analog, but the antagonist did not significantly affect CF excretion in the presence of dietary ascorbic acid.