Yan Yang, W. Sweeney, K. Schneider
Dec 26, 1994
Citations
1
Influential Citations
58
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Aspartimide and its piperidine adduct formed between -Asp-Asn- has been found during an Fmoc-based synthesis of an EGF-like domain in a blood coagulation factor. Model studies with seven susceptible -Asp-X- pentapeptides show that -Asp(Ot-Bu)-Asn(Trt)- and -Asp(Ot-Bu)-Gly- are the most problematic sequences.