J. Richardson
Oct 1, 1974
Citations
0
Influential Citations
15
Citations
Quality indicators
Journal
Mutation research
Abstract
Summary The compound under test was tris-I-(2-methylaziridinyl)phosphineoxide (Metepa), which is a strong alkylating agent. It was injected intraperitoneally to induce chromosomal damage in the bone marrow of mice. 2 closes were applied, separated by 24 h, using 0.05, 0.1, 0.2 and 0.4 mg/kg body weight. The bone marrow was prepared and screened for the presence of micronuclei in polychromatic erythrocytes. A close-dependent increase of micronuclei was observed with no differences between males and females. It is proposed that the test could be used as a routine screening method for mutagenicity.