Maryam Ghalbi Ahangari, M. Moridi Farimani, M. Erfani
Apr 27, 2021
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Journal
Journal of Radioanalytical and Nuclear Chemistry
Abstract
The purpose of this study was to label a trihydroxyflavone with the name of cirsiliol (3’,4’,5-Trihydroxy-6,7-dimethoxyflavone) with Re/[99mTc]Tc. After that in vivo study in C57 mice with Xenograft melanoma tumor was done. Labeling was optimized, and radiochemical analysis was performed. The high radiochemical yield (> 97%) was achieved for cirsiliol which was stable up to 4 h. Rhenium-labeled cirsiliol characterized the complex formation. High tumor uptake was seen for [99mTc]Tc-cirsiliol (2.16 ± 0.23% ID/g) at 1 h post injection. Because of its ability to accumulate and identify tumors, [99mTc]Tc-cirsiliol has a potential to be considered as new radiotracer for melanoma tumor detecting.