M. Shimizu, Y. Ukaji, K. Inomata
Jun 1, 1996
Citations
0
Influential Citations
41
Citations
Journal
Chemistry Letters
Abstract
The catalytic asymmetric 1,3-dipolar cycloaddition of nitrile oxides to an achiral allyl alcohol was achieved by the use of a catalytic amount of diisopropyl (R,R)-tartrate as a chiral auxiliary to afford the corresponding (R)-2-isoxazolines with high enantioselectivity. In order to realize reproducible higher stereoselection, the addition of a small amount of ethereal compound such as 1,4-dioxane was crucial.