G. Liang, Min‐Chao Tong, H. Tao
Oct 9, 2010
Citations
0
Influential Citations
40
Citations
Journal
Advanced Synthesis & Catalysis
Abstract
The direct asymmetric Mannich reaction of glycine Schiff bases with N-tosylimines has been developed with the tetrakis(acetonitrile)copper(I) tetrafluoroborate [Cu(CH 3 CN) 4 BF 4 ]/TF-Bipham-Phos complex. This catalytic system performs well over a broad range of substrates, furnishing anti-adducts of various α,β-diamino acid esters in good yields with up to 94:6 diastereoselectivity and 97% enantioselectivity.