Yaohong Liu, Jie Zhang, Peng‐Fei Xu
Aug 18, 2011
Citations
0
Influential Citations
31
Citations
Journal
The Journal of organic chemistry
Abstract
A highly efficient asymmetric Michael addition of 1-acetylindolin-3-ones to α,β-unsaturated aldehydes is developed to afford 2-substituted indolin-3-one derivatives in high yields (up to 94%) with good stereoselectivities (up to 11:1 dr and 96% ee). The Michael adducts can be transformed into substituted cyclopentyl[b]indoline compounds conveniently without racemization.