Efraím Reyes, J. Vicario, D. Badía
Nov 29, 2006
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Journal
Organic Letters
Abstract
The organocatalytic asymmetric Michael addition of aldehydes to β-nitroacroleine dimethyl acetal has been studied in detail. The reaction took place with excellent yields and high stereoselectivities when a chiral β-amino alcohol such as l-prolinol was employed as the catalyst, leaving a formation of highly functionalized enantioenriched compounds containing two differentiated formyl groups together with a nitro moiety.