Rajendra Maity, S. Pan
Feb 28, 2018
Citations
0
Influential Citations
18
Citations
Journal
Organic & biomolecular chemistry
Abstract
An organocatalytic asymmetric cascade Michael/hemiketalization/acyl transfer reaction between o-hydroxycinnamaldehydes and α-nitroketones is developed. Prolinol TMS ether catalyst in combination with benzoic acid was found to be the most effective for this reaction which proceeds through an equilibrium of lactols to provide a single diastereomer of enantiopure 2,4-disubstituted chromans.