T. Itoh, H. Ishikawa, Y. Hayashi
Sep 3, 2009
Citations
0
Influential Citations
172
Citations
Quality indicators
Journal
Organic letters
Abstract
The asymmetric aldol reaction of isatin derivatives and acetaldehyde has been developed using 4-hydroxydiarylprolinol as a catalyst, affording the aldol products with high enantioselectivity, these products being key intermediates in the synthesis of 3-hydroxyindole alkaloids. Short syntheses of ent-convolutamydine E and CPC-1 and a half fragment of madindoline A and B have been accomplished.