R. Bates, S. Gangwar
1993
Citations
0
Influential Citations
18
Citations
Journal
Tetrahedron-asymmetry
Abstract
Abstract The first synthesis of 3-amino-2-methylpentanoic acids is reported. Comparison of the synthetic 2 R ,3 S and 2 R ,3 S acids with 3-amino-2-methylpentanoic acid obtained by degradation of the antifungal depsipeptide majusculamide C indicates that majusculamide C, 57-normajusculamide C, and the antitumor agents dolastatins 11 and 12 have the 2 S ,3 R configurations at the chiral centers in their β-amino acid component.