J. Charlton, K. Koh, G. Plourde
Nov 1, 1990
Citations
0
Influential Citations
14
Citations
Journal
Canadian Journal of Chemistry
Abstract
An asymmetric synthesis of 2-amino-6,7-dimethoxy-1,2,3,4-tetrahydronaphthalene, which can be converted to the title compound by a literature procedure, is described. The synthesis, starting from 2-amino-4,5-dimethoxybenzoic acid and the acrylate of S-methyl lactate, was accomplished in eight steps in 11% overall yield and > 97% optical purity. Keywords: o-quinodimethanes, Diels–Alder, asymmetric, cycloaddition, induction, diastereoselective, ADTN.