T. Monteil, D. Danvy, J. Plaquevent
Jan 1, 2001
Citations
0
Influential Citations
6
Citations
Journal
Synthetic Communications
Abstract
We describe herein a method providing access to both enantiomers of 3-acetylthio-2-benzylpropionic acid via enzymatic desymmetrization of 2-benzyl-1,3-propanediol. These compounds are respectively the starting materials for the synthesis of ecadotril, and dexecadotril, which are powerful inhibitors of NEP (EC 3.4.24.11) and have been developed as therapeutic agents.