R. Woodward, Bw Au-Yeung, P. Balaram
Jun 1, 1981
Citations
0
Influential Citations
119
Citations
Quality indicators
Journal
Journal of the American Chemical Society
Abstract
In reporting a total synthesis of erythromycin (la) we described in the preceding paper1 the synthesis of the erythronolide A seco acid derivative 2 in optically active form. In this paper we wish to report a successful transformation of 2 to 12 (synthetically equivalent to erythronolide A) via lactonization and also demonstrate that the proper functionalization of a substrate is critical for the successful lactonization.