P. Metz, John Kreutziger, Anne Jäger
Dec 10, 2022
Citations
0
Influential Citations
0
Citations
Journal
Arkivoc
Abstract
The enantioselective mono reduction of 2,2-dimethylcyclopentane-1,3-dione and 2,2-dimethylcyclohexane-1,3-dione was investigated. From the ruthenium, rhodium, and iridium TsDPEN complexes screened with isopropanol or formic acid as the hydrogen donor, the ruthenium complex performed best for both substrates. The resulting hydroxy ketones 3-hydroxy-2,2-dimethylcyclopentanone and 3-hydroxy-2,2-dimethylcyclohexanone, which are important building blocks for natural product synthesis, were obtained in excellent yield with high enantiomeric excess.