M. Watanabe, S. Araki, Y. Butsugan
Mar 1, 1991
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108
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Journal
Journal of Organic Chemistry
Abstract
Chiral 1,2-disubstituted ferrocenyl amino alcohols derived from (R)- and (S)-N,N-dimethyl-1-ferrocenylethylamines catalyze the enantioselective addition of dialkylzincs to aldehydes to afford optically active S and R secondary alcohols. The degree of enantioselectivity increases with increased bulk of substituents near the C-O and C-N bonds of the catalyst. Catalysts with R chirality at the carbon bearing the amino group and planar S chirality at the ferrocene nucleus afford S alcohols, regardless of the chirality of the carbon bearing the hydroxy group