J. Podlech, D. Seebach
Aug 9, 1995
Citations
0
Influential Citations
38
Citations
Journal
Helvetica Chimica Acta
Abstract
The reactions of azetidin-3-ones 6–10, readily available from the amino acids L-alanine, L-phenylalanine, L-valine, L-lysine, and L-aspartic acid, via the corresponding diazo ketones, with nucleophilic reagents such as complex hydrides, Grignard compounds, an ester enolate, and a Wittig ylide give the expected products 11–19 in good yields and mostly in high diastereoselectivities. New amino-alcohol, γ-amino- and γ-amino-β-hydroxy-carboxylic-acid derivatives of known configurations are thus available.