S. J. Patterson, Peter R. Clark, Glynn D. Williams
Sep 28, 2020
Citations
0
Influential Citations
5
Citations
Journal
Tetrahedron Letters
Abstract
Abstract This paper details a simple and efficient 3-component synthesis of 1-substituted 1,2,3-triazoles using a primary amine, 2,2-dimethoxyacetaldehyde and tosylhydrazide. The reaction proceeds in good to excellent yields using either aliphatic or aromatic amine substrates and is tolerant of a wide range of functional groups including electron-rich and deficient aryl groups, terminal alkynes, ketones and highly sterically encumbered amines.