Khaoula Douadi, S. Chafaa, T. Douadi
Oct 5, 2020
Citations
1
Influential Citations
38
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Quality indicators
Journal
Journal of Molecular Structure
Abstract
Abstract Four azoimine quinoline derivatives namely (1Z)-N’-(4-fluorophenyl)-2-oxo-N-quinolin-8-ylpropanehydrazonamide(H2L-F),(1Z)-2-oxo-N′-phenyl-N-quinolin-8-ylpropane hydrazonamide(H2L-H),(1Z)-N’-(4-nitrophenyl)-2-oxo-N-quinolin-8-ylpropane hydrazonamide(H2L-NO2) and (1Z)-N’-(4-bromophenyl)-2-oxo-N-quinolin-8-ylpropane hydrazonamide (H2L-Br) were synthesized and evaluated for their biological activities. At very low concentrations, the four compounds showed a greater antioxidant potential than that of ascorbic acid. The results of the antimicrobial screening indicate that all derivatives have a variable activity against the investigated species, bacteria and fungi. The anti-inflammatory activity of the compounds was found to be in the range of 55–80%. The binding interaction of these molecules with DNA and bovine serum albumin (BSA) was investigated by UV–visible and cyclic voltammetry. The DNA binding study revealed that all the compounds are strongly bound to DNA via intercalation in a spontaneous manner. It was also found that the investigated azoimine quinolines are interacted to BSA with a static quenching process. The choice of these molecules was based on simple synthesis processes, better yield, moderate toxicity, and low cost.