Neeraj Bala, S. Chimni, H. S. Saini
May 1, 2010
Citations
0
Influential Citations
28
Citations
Journal
Journal of Molecular Catalysis B-enzymatic
Abstract
Abstract The phenyl glycidyl ether derivatives have been kinetically resolved with the growing cells of Bacillus alcalophilus MTCC10234 yielding ( S )-epoxides with up to >99% ee and ( R )-diols with up to 89% ee. The enantiomeric ratio ( E ) of up to 67 has been obtained for biohydrolysis process. The effect of different substituents of phenyl glycidyl ether on the biocatalytic efficiency of B. alcalophilus MTCC10234 showed preference for methyl- and chloro-substituted aryl glycidyl ether derivatives whereas nitro-derivatives were transformed at a slower rate. 2,6-Dimethylphenyl glycidyl ether which contains a bulky aryl group having methyl group on both the ortho positions was resolved with an E = 39.