P. Rubiano-Buitrago, F. Duque, M. Puyana
Apr 1, 2019
Citations
0
Influential Citations
9
Citations
Journal
Phytochemistry Letters
Abstract
Abstract Four new diterpenes, 6-epipachydictyol A (1), 6-epidictyol C (2), dictyol L (3), 18-acetoxy-xenianol (4) and the known diterpene dictyoxepin (5) were isolated from the Caribbean alga Dictyota pinnatifida. The structures were deduced by NMR, MS, optical rotation and 3D modeling. Dictyota pinnatifida is a producer of diterpenes with chemotaxonomic significance of group I (prenylated germacrene and derivatives) and III (Xeniane and derivatives), this chemotaxonomic analysis concurs with reported phylogenetic data. Dictyol L showed strong inhibition of Pseudomonas aeruginosa biofilms, better than kojic acid used as control. Dictyoxepin showed mild inhibition of Escherichia coli biofilms. These results suggest that these diterpenes could be used as potential controlling agents of bacterial biofilms recurrent in nosocomial infections.