S. Borman
Sep 12, 1994
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Abstract
Two groups of researchers have independently synthesized balanol, a natural product from fungi that has been shown to be a potent inhibitor of protein kinase C enzymes. The work could lead to the development of balanol analogs as potential new drugs against cancer and a wide range of other diseases associated with protein kinase C activation. One of the total syntheses of balanol has been achieved by John W. Lampe, Philip F. Hughes, Christopher K. Biggers, Shelley H. Smith, and Hong Hu of the department of chemical research at Sphinx Pharmaceuticals Corp., Durham, N.C. [ J. Org. Chem. , 59 , 5147 (1994)]. The other synthesis was carried out by K. C. Nicolaou, Mark E. Bunnage, and Kazunori Koide of the departments of chemistry at Scripps Research Institute, La Jolla, Calif., and the University of California, San Diego [ J. Am. Chem. Soc. , 116 , 8402 (1994)]. Both papers were published last week. The protein kinases are a large family ...