Shijay Gao, Chi Tseng, B. R. Raju
Dec 21, 2009
Citations
0
Influential Citations
2
Citations
Journal
Synlett
Abstract
A one-pot, two-step method for the synthesis of 3-(1- thio)ethyl-1H-indoles is described herein. This simple procedure in- volves the Michael addition of thiols to 3-indoleacrylic acids fol- lowed by in situ decarboxylation of the Michael adduct in the presence of a catalytic amount of K2CO3 in DMF at 100 °C. The method was found to be fairly general with various thiols and dif- ferent 3-indoleacrylic acids.