K. Yeung, Michelle E. Farkas, J. Kadow
May 9, 2005
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Journal
Tetrahedron Letters
Abstract
A convenient and efficient one step, base-catalyzed synthesis of 3,5-disubstituted 1,2,4-triazoles by the condensation of a nitrile and a hydrazide is presented. A diverse range of functionality and heterocycles are tolerated under the reaction conditions developed, and the reactivity of the nitrile partner is relatively insensitive to electronic effects.