Prashishkumar K. Shirsat, Navnath B. Khomane, Sneha H Meshram
Nov 14, 2018
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Influential Citations
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Journal
Synthesis
Abstract
Abstract A novel, one-pot reaction for the synthesis of 3,4-dihydroisoquinolin-2(1H)-one derivatives is developed via a base-mediated three-component reaction of ninhydrin, aniline and acetylenic esters. This diastereoselective reaction takes place in methanol at 70 °C under transition-metal-free conditions, and direct construction of the C–N and C–C bonds is readily achieved via tandem cyclization. These cyclic frameworks are resourceful small molecular keys to many natural products.