Junwen Wang, Shouxiong Chen, Wei Wu
Nov 7, 2019
Citations
0
Influential Citations
5
Citations
Journal
The Journal of organic chemistry
Abstract
2-Trifluoromethylated furans and dihydrofuranols were tunably synthesized from the cyclization of β-ketonitriles with 3-bromo-1,1,1-trifluoroacetone mediated by bases. In addition, dehydration of dihydrofuranol compounds with concentrated sulfuric acid gave another 2-(trifluoromethyl)furans isomer. The developed methodology exhibits excellent functional group tolerance for both aromatic and aliphatic β-ketonitriles.