Yong You, Yongzheng Chen, Xiaomei Zhang
Jul 1, 2018
Citations
0
Influential Citations
3
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A base mediated 1,3-dipolar cycloaddition reaction of methyl 1,4-dioxo-1,4-dihydronaphthalene-2-carboxylate with nitrile oxides in situ generated from N -hydroximoyl chlorides was achieved. With this developed protocol, a range of structurally diverse naphtho[2,3- d ]isoxazole-4,9(3a H ,9a H )-dione derivatives were smoothly obtained in high yields (up to 95%) with up to >20:1 regioselectivities and >20:1 diastereoselectivities under mild conditions. The promising applicability of the protocol was also demonstrated by the further transformations.