Youcan Zhang, Lin Li, Ai-Jun Ma
Oct 31, 2022
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Journal
Organic & biomolecular chemistry
Abstract
A base-promoted [4 + 2] annulation of pyrrole-2-carbaldehyde derivatives with β,γ-unsaturated α-ketoesters for the syntheses of multisubstituted 5,6-dihydroindolizines was developed. Using DBN as a base, the reaction proceeds smoothly under mild conditions to provide the target products in moderate to high yields, and many useful functional groups can be tolerated.