Yue Zhang, Jun-Liang Zeng, Zhen Chen
Oct 20, 2022
Citations
0
Influential Citations
6
Citations
Journal
The Journal of organic chemistry
Abstract
A base-mediated (3 + 2) cycloaddition of trifluoroacetohydrazonoyl chlorides with imidates for the construction of 3-trifluoromethyl-1,2,4-triazoles has been described. This reaction is characterized by readily starting materials, simple reaction conditions, good yields, a broad substrate scope, and excellent regioselectivity. The utility of this protocol has been validated by the synthesis of a drug-like molecule.